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UKALL 14
Trial Overview
A randomized trial for adults with newly diagnosed acute lymphoblastic leukaemia.
For precursor-B lineage ALL, the main aim is to determine if the addition of Rituximab to standard induction chemotherapy results in improved EFS.
For T lineage ALL, the main aim is to determine if the addition of nelarabine following standard induction therapy improves outcomes.
Inclusion criteria
- Subjects must be aged between 25 and 65 years old with acute lymphoblastic leukaemia.
- Newly diagnosed, previously untreated ALL (a steroid pre-phase of 5-7 days is required and can be started prior to registration).
- Written informed consent.
Exclusion criteria
- Known HIV infection.
- Pregnant or lactating women.
- Blast transformation of CML.
- Mature B-cell leukaemia (i.e. Burkitt’s lymphoma t(8;14)(q24;q32) and variant c-myc translocations e.g. t(2;8)(p12;q24), t(8;22)(q24;q11) ).
Principal Investigator
Rod Johnson
Tel:
E-mail: Rod.Johnson@leedsth.nhs.uk
Research Nurse
Amy Humphries
Tel: 0113 2068984
E-mail: Amy.Humphries@leedsth.nhs.uk

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Other trials currently active for Acute Lymphoblastic Leukaemia

UKALL60+
A Phase 2 study for older adults with Acute Lymphoblastic Leukaemia

UKALL2011
United Kingdom National Randomised Trial For Children and Young Adults with Acute Lymphoblastic Leukaemia and Lymphoma 2011