Familial CLL

Trial overview

 

 Genetic study of B-cell chronic lymphocytic leukaemia and other lymphoproliferative disease.

Inclusion criteria

Patients with CLL will be invited to participate by their clinician and be provided with an information sheet summarising the study.

Contact details

Principal Investigator

Dr Peter Hillmen

Tel 0113 2068513

Email peter.hillmen@nhs.net

Research Nurse

Alex Stichler

Tel 0113 2068577

Email alex.stichler@leedsth.nhs.uk



Other trials currently active for Chronic Lymphocytic Leukaemia

ADMIRE

Does the Addition of Mitoxantrone Improve Response to FCR chemotherapy in patients with CLL: A randomised Phase II Trial of fludarabine, cyclophosphamide and rituximab (FCR) with or without mitoxantrone (M) in previously untreated chronic lymphocytic leukaemia

CLL Lenalidomide Maintanence 002 - The Continuum Trial

A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP STUDY OF THE EFFICACY AND SAFETY OF LENALIDOMIDE (REVLIMID®) AS MAINTENANCE THERAPY FOR PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA FOLLOWING SECOND-LINE THERAPY (The Continuum Trial)

GSK OMB 110911

A Phase III, Open Label, Randomized, Multicenter Trial of Ofatumumab Added to Chlorambucil Versus Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukaemia

Primary Outcome Measures:
•Progression-free-survival (PFS)

Secondary Outcome Measures:
•Overall response rate
•Overall survival
•Clinical benefit, safety, tolerability, changes in patient reported outcome measures and pharmacokinetics

Campath CAM203

A Phase II Trial to Evaluate the Efficacy and Safety of Subcutaneously Administered Alemtuzumab (CAMPATH®, MabCampath®) in Patients with Previously Treated B-Cell Chronic Lymphocytic Leukemia

ARCTIC

Attenuated dose Rituximab with ChemoTherapy In CLL: A randomised, phase IIB trial in previously untreated patients with Chronic Lymphocytic Leukaemia (CLL) to compare fludarabine, cyclophosphamide and rituximab (FCR) with FC, mitoxantrone and low dose rituximab (FCM-miniR)

Celgene 009

A Phase 2, Multi-Center, Randomized, Double-Blind, Parallel-Group Study Of

The Safety And Efficacy Of Different Lenalidomide (Revlimid®) Dose Regimens In Subjects

With Relapsed Or Refractory B-Cell Chronic Lymphocytic Leukemia


Tags

leukaemia b-cell chronic lymphocytic leukaemia familial cll